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Activation of two angiotensin‐generating systems in the balloon‐injured artery
Author(s) -
Shiota Naotaka,
Okunishi Hideki,
Fukamizu Akiyoshi,
Sakonjo Hiroshi,
Kikumori Mikito,
Nishimura Takayoshi,
Nakagawa Toshimasa,
Murakami Kazuo,
Miyazaki Mizuo
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81348-4
Subject(s) - chymase , angiotensin ii , renin–angiotensin system , angiotensin converting enzyme , enzyme , medicine , endocrinology , vascular smooth muscle , chemistry , angiotensin ii receptor type 1 , biology , biochemistry , smooth muscle , receptor , blood pressure
Participation of angiotensin II in the myointimal proliferation following a vascular injury was postulated. This study assessed the potential involvement of the local angiotensin II‐forming enzymes in injured arteries of dogs. The potential angiotensin II‐forming enzymes are angiotensin‐converting enzyme (ACE) and chymostatin‐sensitive angiotensin II‐generating enzyme (CAGE) which is highly homologous to or could be identical to the mast cell chymase. Both ACE and CAGE catalyze the conversion of angiotensin I to angiotensin II. We found that the enzymatic activities of ACE and CAGE, and the mRNA levels of ACE and chymase were increased in the injury‐induced hypertrophied vessels. The results suggest that ACE and CAGE participate in the hypertrophy through the production of angiotensin II which is a growth promoter for vascular smooth muscle cells.