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The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity
Author(s) -
Jaffrézou Jean-Pierre,
Laurent Guy
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81337-y
Subject(s) - cytotoxicity , multiple drug resistance , intracellular , ligand (biochemistry) , conjugate , toxin , phenotype , mechanism (biology) , chemistry , biology , drug resistance , pharmacology , microbiology and biotechnology , in vitro , biochemistry , receptor , gene , mathematical analysis , philosophy , mathematics , epistemology
Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand‐toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.