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Opposite regulations by androgenic and thyroid hormones of V1 myosin expression in the two types of rabbit striated muscle: skeletal and cardiac
Author(s) -
d'Albis Anne,
Couteaux René,
Janmot Chantal,
Mira Jean-Claude
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81326-u
Subject(s) - hormone , endocrinology , medicine , skeletal muscle , cardiac ventricle , myosin , cardiac muscle , thyroid , myocyte , gene expression , masticatory force , biology , chemistry , microbiology and biotechnology , gene , ventricle , biochemistry , orthodontics
The finding that VI cardiac myosin is expressed in masticatory skeletal muscles of the rabbit [1] provided a unique opportunity for comparing the hormonal regulation of VI in skeletal and cardiac muscles. Thyroid hormones had no significant effect on the postnatal expression of VI in masticatory muscles, but increased this expression in cardiac ventricles. In contrast, androgenic hormones reduced VI expression in masticatory muscles, but did not affect it significantly in cardiac ventricles. Modulation of VI gene transcription in striated muscle is thus shown here to depend both on the target muscle and on the hormone.