Premium
Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family
Author(s) -
Mulherkar Rita,
Rao Renuka,
Rao Laxmi,
Patki Varsha,
Chauhan V.S.,
Deo Madhav G.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81289-c
Subject(s) - phospholipase a2 , chemistry , biochemistry , biology , enzyme
Enhancing factor (EF), a growth regulatory molecule, isolated from mouse small intestines, has been well characterized in this laboratory. It increases the binding of epidermal growth factor in a unique manner via its own receptor. In the first 20 N‐terminal amino acids sequenced, EF showed 50% homology to human Group II phospholipase A2 (PLA2). Here we propose that EF is yet another, unidentified isoform ofPLA2 which regulates cell proliferation via modulation of EGF binding. To our knowledge, this is the first report implicating PLA2‐II‐like molecules in growth regulation.