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Polysialic acids: potential in drug delivery
Author(s) -
Gregoriadis G.,
McCormack B.,
Wang Z.,
Lifely R.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81177-2
Subject(s) - polysialic acid , chemistry , drug , moiety , phospholipid , drug delivery , biochemistry , liposome , sialic acid , pharmacology , biology , stereochemistry , organic chemistry , cell adhesion , membrane , cell , neural cell adhesion molecule
A number of bacterial polysialic acids were injected intravenously into mice. Half‐lives (up to 40 h) in the blood circulation were dependent on the polysialic acid used, increased by deacylation of their phospholipid moiety, decreased with shorter chain derivatives and appeared to be dose independent. A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half‐life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half‐lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological action.