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Identification and differential expression of yeast SEC23 ‐related gene ( Msec23 ) in mouse tissues
Author(s) -
Wadhwa Renu,
Kaul Sunil C.,
Komatsu Yasuhiko,
Ikawa Yoji,
Sarai Akinori,
Sugimoto Yoshikazu
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81161-r
Subject(s) - yeast , identification (biology) , gene expression , gene , biology , differential (mechanical device) , expression (computer science) , microbiology and biotechnology , genetics , ecology , computer science , physics , programming language , thermodynamics
We have isolated a yeast SEC23 ‐related clone ( Msec23 ) from mouse fibroblast cDNA library. It has an open reading frame of 1721 bp (64% homologous to SEC23 ‐2.3 kb) which can potentially encode a 64.7 kDa protein (61% homologous to 85.4 kDa product of SEC23 ). The deduced Msec23 protein (Msec23p) sequence contains three successive Ig‐like domains at the N‐terminus followed by amphipathic α‐helical regions, suggesting the potential of Msec23p to interact with other protein components. Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts.