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Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum
Author(s) -
Kubohara Yuzuru,
Okamoto Koji,
Tanaka Yoshimasa,
Asahi Ken-ichi,
Sakurai Akira,
Takahashi Nobutaka
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81114-f
Subject(s) - dictyostelium discoideum , inducer , stalk , cellular differentiation , dictyostelium , slime mold , microbiology and biotechnology , mutant , biology , mycetozoa , strain (injury) , chemistry , biochemistry , gene , anatomy , horticulture
Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB‐001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). The chemical structure of this substance is very similar to that of stalk cell differentiation‐inducing factor (DIF) isolated from the cellular slime mould, Dictyostelium discoideum . We examined the effects of differanisole A on Dictyostelium HM44 cells, a mutant strain which is defective in DIF production, and found this substance to be an inducer of stalk cell differentiation in D . discoideum .