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Structural modifications associated with the change in Ca 2+ sensitivity on activation of m‐calpain
Author(s) -
Brown Nicholas,
Crawford Catherine
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81112-d
Subject(s) - chemistry , calpain , sensitivity (control systems) , biophysics , biochemistry , enzyme , biology , electronic engineering , engineering
Autolysis of the Ca 2+ ‐dependent cysteine protease m‐calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca 2+ sensitivity. The appearance of increased Ca 2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.