Premium
Starvation effect on rat kidney peroxisomal and microsomal fatty acid oxidation
Author(s) -
Orellana Myriam,
Fuentes Oscar,
Valdés Elena
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81111-c
Subject(s) - peroxisome , lauric acid , hydroxylation , microsome , biochemistry , fatty acid , catabolism , chemistry , beta oxidation , metabolism , substrate (aquarium) , biology , enzyme , receptor , ecology
Microsomal lauric acid 12‐hydroxy lauric acid (ω)‐hydroxylation and fatty acid peroxisomal β‐oxidation were studied in kidney tissue from starved rats. Starvation increased the microsomal ω‐hydroxylation and peroxisomal β‐oxidation of fatty acids with a high correlation between both processes. Earlier, we reported similar results in liver. Our results support the hypothesis that the role of microsomal fatty acids ω‐hydroxylation is the generation of substrate for peroxisomal β‐oxidation, with the final purpose of contributing to a catabolic or gluconeogenic pathway from fatty acids.