Premium
Monoclonal anti‐biotin antibodies simulate avidin m the recognition of biotin
Author(s) -
Bagçi Hasan,
Kohen Fortune,
Kusçuoglu Unsal,
Bayer Edward A.,
Wilchek Meir
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81108-c
Subject(s) - biotin , avidin , streptavidin , monoclonal antibody , biotinylation , chemistry , biochemistry , microbiology and biotechnology , antibody , biology , immunology
The sequence of the V H gene of a monoclonal anti‐biotin antibody was determined. Biotin‐binding motifs, similar to those in avidin and streptavidin, were identified in complementarity determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.