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The VP35 and VP40 proteins of filoviruses
Author(s) -
Bukreyev A.A.,
Volchkov V.E.,
Blinov V.M.,
Netesov S.V.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81107-b
Subject(s) - marburg virus , open reading frame , ebolavirus , ebola virus , vp40 , messenger rna , filoviridae , biology , transcription (linguistics) , virology , rna , computational biology , microbiology and biotechnology , gene , genetics , peptide sequence , virus , philosophy , linguistics , paramyxoviridae , viral disease
The fragments of genomic RNA sequences of Marburg (MBG) and Ebola (EBO) viruses are reported. These fragments were found to encode the VP35 and VP40 proteins. The canonic sequences were revealed before and after each open reading frame. It is suggested that these sequences are mRNA extremities and at the same time the regulatory elements for mRNA transcription. Homology between the MBG and EBO proteins was discovered.