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Tissue‐specific isoforms of the bovine mitochondrial ATP synthase γ‐subunit
Author(s) -
Matsuda Chie,
Endo Hitoshi,
Hirata Hajime,
Morosawa Hideaki,
Nakanishi Makoto,
Kagawa Yasuo
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81089-i
Subject(s) - atp synthase , gene isoform , protein subunit , biochemistry , mitochondrion , chemistry , atp synthase gamma subunit , biology , enzyme , atpase , atp hydrolysis , gene
Tissue‐specific isoforms of the γ‐subunit of the bovine F 0 F 1 ‐ATP synthase were identified for the first time. The two isoforms, heart and liver type, were generated by alternative splicing, the liver‐type RNA transcript containing a 37‐nucleotide sequence as a cassette exon. Protein sequencing of the C‐terminal fragments of the two isoforms of the F 1 γ‐subunit indicated that the liver‐type isoform had an additional aspartate residue at the C terminus, not present in the heart type one.