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TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture
Author(s) -
del Marmol V.,
Ito S.,
Jackson I.,
Vachtenheim J.,
Berr P.,
Ghanem G.,
Morandini R.,
Wakamatsu K.,
Huez G.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81010-w
Subject(s) - tyrosinase , melanin , chemistry , pigment , messenger rna , biochemistry , cell culture , microbiology and biotechnology , enzyme , gene , biology , genetics , organic chemistry
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase‐related protein‐1 (TRP‐1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP‐1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP‐1 in the eumelanin synthesis pathway.