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Stimulation‐induced expression of slow muscle myosin in a fast muscle of the rat
Author(s) -
Mayne Caroline N.,
Mokrusch Thomas,
Jarvis Jonathan C.,
Gilroy Stephen J.,
Salmons Stanley
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81008-n
Subject(s) - myosin , gene isoform , stimulation , hindlimb , myh7 , chemistry , myosin light chain kinase , anatomy , microbiology and biotechnology , biology , endocrinology , medicine , biochemistry , gene
Fast muscles of the rat hind limb were stimulated continuously at 10 or 20 Hz for periods of 55–61 days by means of an implantable neuromuscular stimulator. Gel electrophoresis clearly demonstrated the presence in stimulated muscles of slow myosin light and heavy chains, although fast isoforms were still present in all cases. Thus, contrary to previous reports, induction of slow myosin isoforms does occur in this, as in other, mammalian species. The time course of the response to stimulation appears to be more extended than that seen in the rabbit.