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A gene homologous to the reg gene is expressed in the human pancreas
Author(s) -
Bartoli Catherine,
Gharib Bouchra,
Giorgi Dominique,
Sansonetti Alice,
Dagorn Jean-Charles,
Bergé-Lefranc Jean-Louis
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81006-l
Subject(s) - gene , homologous chromosome , biology , exon , pancreas , genomic dna , gene expression , nucleic acid sequence , genetics , oligonucleotide , peptide sequence , amino acid , microbiology and biotechnology , biochemistry
We have determined the nucleotide sequence of reg1 a human genomic DNA fragment homologous to the reg gene which is expressed in the exocrine pancreas and regenerating islets. Sequence comparisons of reg and reg1 suggested similar exonintron organisation. Based on this assumption, specific oligonucleotides for reg1 exons were used to demonstrate expression of the reg1 gene in pancreas and liver. The proteins encoded by reg and reg1 comprise 166 amino acids and differ by 22 amino acids only.