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Molecular cloning and developmental expression of human cardiac troponin T
Author(s) -
Mesnard Laurence,
Samson Françoise,
Espinasse Isabelle,
Durane Jacques,
Neveux Jean-Yves,
Mercadier Jean-Jacques
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80981-y
Subject(s) - skeletal muscle , complementary dna , troponin complex , messenger rna , troponin , cdna library , troponin t , biology , cardiac muscle , microbiology and biotechnology , cloning (programming) , fetus , molecular cloning , gene expression , medicine , endocrinology , gene , genetics , pregnancy , myocardial infarction , computer science , programming language
We have isolated a full‐size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post‐natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down‐regulated during further development.