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Molecular cloning of a cDNA encoding a novel small GTP‐binding protein
Author(s) -
Koda Toshiaki,
Kakinuma Mitsuaki
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80957-v
Subject(s) - complementary dna , cloning (programming) , molecular cloning , computational biology , gtp' , microbiology and biotechnology , chemistry , biology , genetics , biochemistry , gene , computer science , enzyme , programming language
A cDNA encoding a small GTP‐binding protein, S10, was cloned from Jurkat cells. The deduced amino acid sequence of S10 had the structural features characteristic to this family of proteins with highest homology to rab subfamily. Northern blot analysis revealed that this gene is expressed only in lymphoid cell lines and a histiocytic leukemia, U937. Hence, it should have a specialized function in cells derived from the hematopoietic stem cell.