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Effects of anions on the Ca 2+ , H + and electrical gradients formed by the sarcoplasmic reticulum ATPase in reconstituted proteoliposomes
Author(s) -
Yu Xiang,
Inesi Giuseppe
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80948-t
Subject(s) - endoplasmic reticulum , chaotropic agent , chemistry , biophysics , vesicle , ion pump , membrane , ion , hofmeister series , membrane potential , atpase , contraction (grammar) , biochemistry , enzyme , biology , organic chemistry , endocrinology
The chaotropic character of several ions determines their partition on membrane interfaces with aqueous media as predicted by the Hofmeister series. However, specific characteristics of each individual ion determine its ability to cross the membrane and to influence Ca 2+ , H + and electrical gradients produced by the sarcoplasmic reticulum (SR) Ca 2+ pump in reconstituted proteoliposomal vesicles. Specific effects of this kind may be relevant to a variety of biological systems, including the excitation‐contraction coupling of muscle fibers in which SR plays a prominent role.