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Extended in vivo blood circulation time of fluorinated liposomes
Author(s) -
Santaella Catherine,
Frézard Frédéric,
Vierling Pierre,
Riess Jean G.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80860-w
Subject(s) - liposome , in vivo , polyethylene glycol , chemistry , vesicle , peg ratio , membrane , cholesterol , drug carrier , chromatography , biophysics , biochemistry , drug delivery , biology , organic chemistry , microbiology and biotechnology , finance , economics
The clearance from blood circulation of fluorinated liposomes made with perfluoroalkylated phosphatidylcholines was investigated in mice using liposome‐entrapped 5(6)‐carboxyfluorescein. The presence of a fluorinated core inside the membrane strongly retards their blood clearance. The fluorinated vesicles showed circulation half‐lives of up to 8.6 h, which are 6–13 and 3–6 times larger than those of similarly sized conventional distearoylphosphatidylcholine and distearoylphosphatidylcholine/cholesterol liposomes, respectively. Their blood clearance was similar to that of some polyethylene glycol (PEG)‐labelled ‘stealth’ liposomes and was dose‐independent in a 3.3–330 body weight dose range.