Premium
Effect of catalytically active recruited crystallins on lens metabolism
Author(s) -
Reddy M.C.,
Groth-Vasselli Barbara,
Sharon Ashwini,
Farnsworth Patricia N.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80748-j
Subject(s) - nad+ kinase , metabolite , crystallin , biochemistry , chemistry , metabolism , lens (geology) , pyridine , alpha (finance) , biology , enzyme , medicine , medicinal chemistry , paleontology , construct validity , nursing , patient satisfaction
The impact on duck lens metabolism of recruited ϵ‐crystallin/LDH‐B4 and τ‐crystallin/enolase was investigated by NMR spectroscopy. A comparison of the duck lens metabolite profile with that of the calf in which recruited crystallins are absent revealed significant increases in ATP, α‐glycerophosphate (α‐GP) and pyridine dinucleotide concentrations. The alterations in the concentrations of ATP and α‐GP appear to be related to both the high concentration of NAD and the elevated reduced to oxidized NADH/NAD + ratio.