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The role of apoptotic and necrotic processes in cytolysis mediated by LAK cells with different phenotypes
Author(s) -
Sashchenko L.P.,
Kabanova O.D.,
Blishchenko L.Yu.,
Lukjianova T.I.,
Satpaev D.K.,
Chertov O.Yu.,
Gnuchev N.V.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80744-f
Subject(s) - cytolysis , lymphokine activated killer cell , apoptosis , cd16 , cd8 , k562 cells , phenotype , cytotoxic t cell , necrosis , microbiology and biotechnology , programmed cell death , cd3 , biology , chemistry , immunology , in vitro , antigen , interleukin 21 , biochemistry , gene , genetics
The role of necrotic and apoptotic pathways in cytolysis mediated by LAK cells was studied. The contribution of necrotic and apoptotic processes to cytolysis depends both on the LAK cells' phenotype and the type of target cells. CD16+/CD8+/CD− LAK cells induced necrosis of K562 and L929 target cells. The cell death induced by CD3+/CD8+/CD1− LAK cells was found to include features of apoptotic and necrotic processes.