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Electrophoretic analysis of myosin heavy chain isoform patterns in extraocular muscles of the rat
Author(s) -
Asmussen Gerhard,
Traub Irmtrud,
Pette Dirk
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80738-g
Subject(s) - extraocular muscles , myosin , gene isoform , anatomy , skeletal muscle , biology , myh7 , immunoglobulin light chain , myosin light chain kinase , chemistry , microbiology and biotechnology , biochemistry , genetics , antibody , gene
Six oculorotatory muscles and the levator palpebrae muscle of the rat were analysed by SDS‐PAGE for their myosin heavy chain (MHC) isoform patterns. Oculorotatory muscles display a marked predominance of fast MHC isoforms. They contain, in addition to the slow (MHCI) and fast (MHCIIb, MHCIId, MHCIIa) skeletal MHCs, the neonatal MHC neo and the extraocular MHC eom . The levator palpebrae, generally assumed to be a member of the extraocular muscle group because of its innervation by the ocolumotor nerve, does not contain MHC neo and MHC eom . It resembles a fast‐twitch skeletal muscle with a predominance of MHCIId.