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Electrophoretically defined myosin heavy chain patterns of single human muscle spindles
Author(s) -
Pedrosa-Domellöf Fatima,
Gohlsch Bärbel,
Thornell Lars-Eric,
Pette Dirk
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80737-f
Subject(s) - gene isoform , myosin , major histocompatibility complex , biology , myh7 , microbiology and biotechnology , heavy chain , myosin light chain kinase , biochemistry , gene
At least four myosin heavy chain (MHC) isoforms were separated by SDS‐PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHC emb . A faint band, moving slightly faster than MHC emb , most likely represents a neonatal/fetal MHC isoform. A prominent band, moving between the latter and the slow isoform is suggested to represent a hitherto unidentified, spindle‐specific MHC isoform, MHC if .