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Aspirin induces non‐enzymatic formation of platelet‐activating factor from lyso platelet‐activating factor
Author(s) -
Mabuchi-Itoh Kiyoko,
Sugiura Takayuki,
Cheng Neng-neng,
Waku Keizo
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80639-c
Subject(s) - aspirin , platelet , lyso , platelet activating factor , platelet factor 4 , chemistry , enzyme , pharmacology , medicine , endocrinology , biochemistry , scintillator , detector , electrical engineering , engineering
Substantial amounts of platelet‐activating factor (PAF) were formed when lysoPAF was mixed with aspirin (e.g. 0.04% of added lysoPAF (200 nmol) was converted to PAF when mixed with aspirin (2 μmol) for 1 h). Non‐enzymatic formation of PAF from aspirin and lysoPAF also occurs in the aqueous solution or in organic solvents in time‐dependent and dose‐dependent manners. Possible meanings of the non‐enzymatic formation of PAF are discussed.