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Neurogranin, a B‐50/GAP‐43‐immunoreactive C‐kinase substrate (BICKS), is ADP‐ribosylated
Author(s) -
Coggins Philip J.,
McLean Kim,
Zwiers Henk
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80450-9
Subject(s) - neurogranin , biology , cytosol , biochemistry , kinase , chemistry , microbiology and biotechnology , enzyme , protein kinase c
Neurogranin is a neurone‐specific, B‐50‐immunoreactive C‐kinase substrate that has limited homology to, but considerable biochemical similarity to B‐50/GAP43. The most significant differences between these two proteins are their cellular localisation and molecular mass (Neurogranin, 7.5 kDA cytosolic; and B‐50, 25 kDa membranal). An understanding of the similarities and differences between Neurogranin and B‐50 may facilitate the elucidation of their hitherto elusive functions in the nervous system. The results of the present study demonstrate that, in common with B‐50, Neurogranin is a substrate for ADP‐ribosyltransferases. This finding is discussed with regard to the concept of molecular flexibility of B‐50‐like proteins as the basis of their putatively diverse roles in the nervous system.