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Intraorganellar localization of CoASH‐independent phytanic acid oxidation in human liver peroxisomes
Author(s) -
Pahan Kalipada,
Singh Inderjit
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80395-b
Subject(s) - phytanic acid , peroxisome , biochemistry , beta oxidation , fatty acid , chemistry , biology , gene
In human tissues phytanic acid is α‐oxidized to pristanic acid in peroxisomes. Studies of the intraorganellar site of α‐oxidation of [1‐ 14 C]phytanic acid to pristanic acid in peroxisomes isolated from human liver demonstrate that phytanoyl‐CoA ligase is present in the peroxisomal membrane and that the enzyme system for α‐oxidation of phytanic acid to pristanic acid is in the peroxisomal matrix. In contrast to the β‐oxidation system for fatty acids, the substrate for α‐oxidation is free phytanic acid. The studies described in this manuscript report a novel fatty acid oxidation system where the substrate for the enzyme system is free fatty acid; however, phytanoyl‐CoA ligase regulates the α‐oxidation of phytanic acid at the organellar (peroxisomal) level.