Premium
Expression of glutathione S‐transferase P‐form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone
Author(s) -
Aoki Yasunobu,
Matsumoto Michi,
Suzuki Kazuo T.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80386-9
Subject(s) - microbiology and biotechnology , glutathione , glutathione s transferase , protein kinase a , kinase , biology , transcription factor , enzyme , cytochrome p450 , biochemistry , chemistry , gene
Glutathione S‐transferase P‐form (GST‐P, EC 2.5.1.18) mRNA was expressed by epidermal growth factor as well as by 3,4,5,3',4'‐penta‐chlorinated biphenyl (PenCB) in primary cultured rat liver parenchymal cells. The expression of GST‐P was suppressed by inhibitors of protein kinase C and dexamethasone, an antagonist of AP‐1 transcription factor activity, whereas expression of cytochrome P4501A2 by PenCB was not affected by these reagents. The AP‐1 related transcription factor may be essential for the expression of GST‐P by PenCB as also may be a protein kinase C type enzyme.