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Potassium regulates plasma testosterone and renal ornithine decarboxylase in mice
Author(s) -
Sánchez-Capelo Amelia,
Cremades Asunción,
Tejada Francisco,
Fuentes Teodomiro,
Peñafiel Rafael
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80369-6
Subject(s) - medicine , endocrinology , testosterone (patch) , potassium , kidney , renal hypertrophy , chemistry , ornithine decarboxylase , androgen , enzyme , ornithine , biology , biochemistry , hormone , amino acid , diabetic nephropathy , organic chemistry , arginine
Potassium deficiency produced different effects in the kidney of male or female mice. While in female, potassium deficiency caused a marked renal hypertrophy with no significant changes in testosterone‐regulated enzymes, such as ornithine decarboxylase and β‐glucuronidase, in the male the same treatment provoked a marked fall of these enzymes owing to a dramatic decrease in plasma testosterone. Potassium replenishment restored plasma testosterone and renal enzymatic activities. These results show for the first time, that potassium modulates circulating testosterone and suggest that this cation could exert an important regulatory role in controlling androgen actions.