Premium
Vitamin B 6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver
Author(s) -
Oka Tatsuzo,
Komori Naomi,
Kuwahata Masashi,
Sassa Toshihiro,
Suzuki Isao,
Okada Mitsuko,
Natori Yasuo
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80318-o
Subject(s) - gene expression , microbiology and biotechnology , polymerase , rna , glyceraldehyde 3 phosphate dehydrogenase , rna polymerase , rna polymerase ii , biology , messenger rna , transcription (linguistics) , rna polymerase i , gene , chemistry , biochemistry , promoter , linguistics , philosophy
The effect of vitamin B 6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B 6 ‐deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for β‐actin and glyceraldehyde‐3‐phosphate dehydrogenase, and the content of poly(A) + RNA were also increased in vitamin deficiency. These observations suggest that vitamin B 6 influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.