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Repression of histone H5 gene expression in chicken mature erythrocytes is correlated with reduced DNA‐binding activities of transcription factors SP1 and GATA‐1
Author(s) -
Sun Jian-Min,
Penner C.Gail,
Davie James R.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80313-j
Subject(s) - histone , microbiology and biotechnology , enhancer , transcription factor , biology , promoter , gene , transcription (linguistics) , gene expression , chemistry , biochemistry , linguistics , philosophy
During the final stages of erythroid maturation, the expression of the chicken histone H5 gene ceases. The histone H5 promoter has binding sites for Sp1 and UPE‐binding protein. The 3' histone H5 enhancer has binding sites for Sp1, GATA‐1 and NF1. Here, we show that the DNA‐binding activities of transcription factors Sp1 and GATA‐1 is reduced 5‐ to 10‐fold in mature cells, while the activities of UPE‐binding protein and NF1 remain the same in mature and immature erythrocytes. The reduced activities of Sp1 and GATA‐1 may contribute to the inactivation of the histone H5 gene in mature erythrocytes.