Premium
Biosynthesis of vitamin B 12
Author(s) -
Scott A.I.,
Roessner C.A.,
Stolowich N.J.,
Spencer J.B.,
Min C.,
Ozaki S.-I.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80306-f
Subject(s) - biosynthesis , chemistry , enzyme , stereochemistry , contraction (grammar) , biochemistry , biology , endocrinology
In the vitamin B 12 biosynthetic pathway the enzymes responsible for the conversion of precorrin‐3 to precorrin‐4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans . CobG catalyzes the oxidation of precorrin‐3 to precorrin‐3x (a hydroxy lactone) whereas CobJ is a SAM‐dependent C‐17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.