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Calcitonin gene expression in normal human liver
Author(s) -
Bracq S.,
Machairas M.,
Clement B.,
Pidoux E.,
Andreoletti M.,
Moukhtar M.S.,
Jullienne A.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80288-6
Subject(s) - calcitonin , calcitonin receptor , autocrine signalling , paracrine signalling , receptor , radioimmunoassay , medicine , endocrinology , calcitonin gene related peptide , messenger rna , human liver , biology , gene , neuropeptide , biochemistry , in vitro
Immunoreactive calcitonin (CT) is present in liver. This could represent hormone synthesized by liver cells, degraded or bound to specific receptors reported in this organ. We report here that the calcitonin gene is expressed in liver. We proved this by demonstrating, by PCR amplification using specific primers, the presence of calcitonin messenger in human liver and in primary cultures of human hepatocytes and detected by radioimmunoassay CT in hepatic tissues and cells. The synthesis of hormone by liver that also possesses specific receptors for CT favors the presence of an autocrine or paracrine system involving calcitonin in this organ.