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Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor
Author(s) -
Graham Annette,
Hogg Neil,
Kalyanaraman Balaraman,
O'Leary Vanessa,
Darley-Usmar Victor,
Moncada Salvador
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80269-z
Subject(s) - peroxynitrite , scavenger receptor , chemistry , biochemistry , low density lipoprotein , nitric oxide , receptor , antioxidant , macrophage , lipid peroxidation , lipoprotein , superoxide , cholesterol , in vitro , enzyme , organic chemistry
Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α‐tocopherol to α‐tocopherol quinone.