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Molecular cloning and expression of a novel truncated form of chicken trkC
Author(s) -
Okazawa Hitoshi,
Kamei Masaki,
Kanazawa Ichiro
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80216-h
Subject(s) - tropomyosin receptor kinase c , tropomyosin receptor kinase b , trk receptor , biology , neurotrophin , tropomyosin receptor kinase a , receptor tyrosine kinase , neurotrophin 3 , tyrosine kinase , low affinity nerve growth factor receptor , microbiology and biotechnology , ror1 , genetics , neurotrophic factors , brain derived neurotrophic factor , kinase , signal transduction , receptor , platelet derived growth factor receptor , growth factor
The trk family of tyrosine protein kinase genes serves crucial roles for the development of the nervous system and the survival of neurons. The members of this gene family, trk , trkB and trkC , bind a distinct neurotrophin of the nerve growth factor (NGF) gene family, and trigger the intracellular signals which elicit trophic and differentiating effects on neurons. Adding to these neurotrophic receptor kinases, the truncated forms without the tyrosine kinase domain have been cloned and characterized. It has been thought that the existence of truncated forms is limited to trkB ; however, very recently the truncated trkC has been cloned in rat [(1993) Neuron 10, 963‐974; (1993) Neuron 10, 975‐990]. We independently approached and molecularly cloned a truncated form which belongs to the chicken trkC . The truncated trkC possesses the binding and the transmembrane domains but not the tyrosine kinase domain. Northern blot analysis shows that the truncated form is preferentially expressed in the adult central nervous system. The truncated form is scarcely expressed during the embryonic stages. The conservation of the truncated trkC beyond species suggests they have specific functions.