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Sunlight‐induced mutagenicity of a common sunscreen ingredient
Author(s) -
Knowland John,
McKenzie Edward A,
McHugh Peter J,
Cridland Nigel A
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80141-g
Subject(s) - sunlight , sunburn , chemistry , ingredient , carcinogen , sun protection , photochemistry , food science , organic chemistry , dermatology , medicine , physics , astronomy
We have tested the mutagenicity of a UV‐B sunscreen ingredient called Padimate‐O or octyl dimethyl PABA, which, chemically speaking, is identical to an industrial chemical that generates free radicals when illuminated. It is harmless in the dark but mutagenic in sunlight, attacking DNA directly. A commercial sunscreen containing Padimate‐O behaves in the same way. UV‐A in sunlight also excites Padimate‐O, although less than UV‐B. Some related compounds, including a known carcinogen, behave similarly. As mutagens may be carcinogenic, our results suggest that some sunscreens could, while preventing sunburn, contribute to sunlight‐related cancers.