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An interaction of β‐amyloid with aluminium in vitro
Author(s) -
Exley Christopher,
Price Nicholas C.,
Kelly Sharon M.,
Birchall J.Derek
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80137-j
Subject(s) - circular dichroism , aluminium , pathogenesis , in vitro , amyloid (mycology) , chemistry , biophysics , biochemistry , crystallography , pathology , medicine , biology , organic chemistry , inorganic chemistry
We have used circular dichroism spectroscopy to confirm that, in a membrane‐mimicking solvent, AβP(1–40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and β‐amyloid and may have important implications for the pathogenesis of Alzheimer's disease.