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Inactivation of synovial fluid α 1 ‐antitrypsin by exercise of the inflamed rheumatoid joint
Author(s) -
Zhang Zhi,
Farrell Adrian J.,
Blake David R.,
Chidwick Keith,
Winyard Paul G.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80123-c
Subject(s) - rheumatoid arthritis , synovial fluid , in vivo , chemistry , medicine , in vitro , arthritis , endocrinology , biochemistry , pathology , osteoarthritis , biology , alternative medicine , microbiology and biotechnology
α 1 ‐Antitrypsin (α 1 AT) is known to be oxidised by reactive oxygen species both in vitro and in vivo, leading to its inactivation. We report here that synovial fluid (SF) α 1 AT is inactivated during exercise of the knee‐joints of rheumatoid arthritis (RA) patients. Sequential SF sampling from exercised RA patients showed a marked decrease in the mean activity of α 1 AT after exercise with no change in the molecular forms of α 1 AT. No such inactivation was found in the control (continuously resting) RA patients. We suggest that oxidation may contribute to α 1 AT inactivation as a consequence of ‘hypoxic‐reperfusion’ injury after exercise of the inflamed joint.