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Control of muscle pyruvate oxidation during late pregnancy
Author(s) -
Sugden Mary C.,
Holness Mark J.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80091-8
Subject(s) - medicine , nefa , pyruvate dehydrogenase complex , endocrinology , skeletal muscle , starvation , ketone bodies , beta oxidation , pregnancy , chemistry , cardiac muscle , dehydrogenase , pyruvate kinase , enzyme , metabolism , biology , biochemistry , insulin , glycolysis , genetics
Despite significant increases in circulating concentrations of lipid fuels (triacylglycerol, non‐esterified fatty acids (NEFA) and ketone bodies) in late‐pregnant rats sampled in the fed (absorptive) state, cardiac and skeletal muscle active pyruvate dehydrogenase (PDH a ) activities remained comparable with those observed in fed, age‐matched virgin controls. Cardiac PDH a activity was suppressed in response to acute (6 h) starvation in late‐pregnant (as well as virgin) rats: this inactivation was opposed by inhibition of mitochondrial long‐chain FA oxidation. Starvation (6 h) also led to PDH inactivation in skeletal muscles of late‐pregnant, but not virgin, rats. Starvation for 24 h led to further suppression of cardiac PDH a activity and was associated with significant increases in PDH kinase activities in both virgin and late‐pregnant rats. Late pregnancy did not itself influence cardiac PDH kinase activity.