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Human γ‐interferon expression in the mammary gland of transgenic mice
Author(s) -
Dobrovolsky V.N.,
Lagutin O.V.,
Vinogradova T.V.,
Frolova I.S.,
Kuznetsov V.P.,
Larionov O.A.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80063-z
Subject(s) - mammary gland , transgene , genetically modified mouse , biology , complementary dna , interferon , gene , gene expression , microbiology and biotechnology , endocrinology , medicine , immunology , genetics , cancer , breast cancer
Transgenic mice carrying a hybrid gene consisting of ovine β‐lactoglobulin gene sequences and human γ‐interferon (hIFN‐g) cDNA were produced. hIFN‐g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN‐g in the milk was estimated as being ca. 1800 IU/ml. The hIFN‐g ability to express in the mammary gland was found in the progeny of transgenic founder male.