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Growth response to 4‐hydroxy‐ l ‐threonine of Escherichia coli mutants blocked in vitamin B 6 biosynthesis
Author(s) -
Drewke Christel,
Notheis Caroline,
Hansen Ursula,
Leistner Eckhard,
Hemscheidt Thomas,
Hill Robert E.,
Spenser Ian D.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80005-f
Subject(s) - threonine , biosynthesis , escherichia coli , biochemistry , mutant , chemistry , decarboxylation , serine , phosphorylation , enzyme , catalysis , gene
Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B 6 ) showed a growth response to 4‐hydroxy‐ l ‐threonine. This observation constitutes the first direct evidence in support of the view that 4‐hydroxy‐ l ‐threonine is implicated in the biosynthesis of vitamin B 6 . 1‐Aminopropan‐2,3‐diol, the decarboxylation product of 4‐hydroxy‐ l ‐threonine, does not support the growth of these mutants. Deuterium from deuterium‐labelled 1‐aminopropan‐2,3‐diol was not incorporated into pyridoxol.