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Dynamics of intermediate filaments
Author(s) -
Georgatos Spyros D.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)80001-b
Subject(s) - dynamics (music) , biophysics , chemistry , physics , biology , acoustics
Intermediate filaments (IFs) have always been considered as the most static and ‘skeletal’ cellular elements. This view is now changing: new information reveals that IFs exchange subunits at steady‐state, that IF networks can be assembled de novo, and that IF proteins are subject to elaborate chemical modification and de‐modification during mitosis. I describe below some of the key observations which have made us realize that IFs are dynamic structures. I also discuss some of the remaining questions pertinent to the pathways of IF assembly under in vivo conditions.