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Nucleolar and cytoplasmic localization of annexin V
Author(s) -
Sun Jiuru,
Salem Hatem H.,
Bird Philip
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81519-r
Subject(s) - nucleolus , annexin a2 , cytoplasm , subcellular localization , annexin , microbiology and biotechnology , umbilical vein , nucleus , immunofluorescence , chemistry , biology , antibody , flow cytometry , biochemistry , immunology , in vitro
The subcellular localization of annexin V in cultured human umbilical vein endothelial cells, epithelial cells and fibroblasts was examined. Indirect immunofluorescence and immunoblotting studies using affinity‐purified anti‐annexin V antibodies revealed that annexin V is located within the cytoplasm and nucleus of these cells. Further examination and direct binding studies showed that annexin V within the nucleus is associated with the nucleolus. These findings suggest that annexin V may play a role in a nucleolar function, such as ribosome assembly and transport.