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Human urokinase contains Ga1NA c β(1‐4)[Fucα(1‐3)]G1cNA c β(1‐2) as a novel terminal element in N ‐linked carbohydrate chains
Author(s) -
Bergweff Aldert A.,
Thomas-Oates Jane E.,
van Oostrum Jan,
Kamerling Johannis P.,
Vliegenthart Johannes F.G.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81512-k
Subject(s) - terminal (telecommunication) , chemistry , carbohydrate , stereochemistry , urokinase , biochemistry , biology , computer science , genetics , telecommunications
Structural analysis of enzymically released N ‐linked carbohydrate chains of human urokinase (urinary‐type plasminogen activator) by 1 H NMR spectroscopy and FAB‐MS demonstrated that the N ‐linked oligosaccharides on the only N ‐glycosylation site contain diantennary structures with the novel Ga1NA c β(1‐4)[Fucα(1‐3)]G1cNA c β(1‐2) element in the upper or the lower branch.