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Na + ‐dependent AIB transport by neuroblastoma cells
Author(s) -
del Castillo-Olivares Antonio,
Medina Miguel Angel
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81451-q
Subject(s) - isobutyric acid , neuroblastoma , cell culture , tyrosine , amino acid , cysteine , chemistry , oncogene , cancer research , cell , microbiology and biotechnology , biology , biochemistry , genetics , cell cycle , enzyme
Na + ‐dependent amino isobutyric acid transport by two neuroblastoma cell lines with and without amplification of the oncogene N‐ myc is studied. Surprisingly, the contribution of system A is greater in the cell line showing no N‐ myc amplification. Preliminary data support a role for essential tyrosine and cysteine residues in the active center of the carriers, mainly in system A.