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Dopaminergic stimulation up‐regulates the in vivo expression of brain‐derived neurotrophic factor (BDNF) in the striatum
Author(s) -
Okazawa Hitoshi,
Murata Miho,
Watanabe Masahiko,
Kamei Masaki,
Kanazawa Ichiro
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81430-t
Subject(s) - dopaminergic , striatum , brain derived neurotrophic factor , neurotrophic factors , dopamine , stimulation , in vivo , chemistry , endocrinology , medicine , neuroscience , biology , receptor , microbiology and biotechnology
We investigated the effect of dopamine on the in vivo expression of brain‐derived neurotrophic factor (BDNF) in the striatum of mouse. BDNF mRNA expression in the striation, which was Quantified with the reverse transcriptase polymerase chain reaction, was up‐repulated from 2 h after oral administration of levodopa, a precursor of dopamine. The increase was sustained for 16 h. Co‐administrstion of haloperidol partially inhibited dopamine‐induced BDNF enhancement. These data suggest that dopaminergic stimulation directly promotes the expression of BDNF in the striatum in vivo.