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Differential expression of keratan sulphate proteoglycans fibromodulin, lumican and aggrecan in normal and fibrotic rat liver
Author(s) -
Krull N.B.,
Gressner A.M.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81407-d
Subject(s) - lumican , aggrecan , proteoglycan , keratan sulfate , chemistry , gene expression , glycosaminoglycan , microbiology and biotechnology , biochemistry , gene , biology , extracellular matrix , medicine , pathology , osteoarthritis , decorin , alternative medicine , articular cartilage
In this study we investigated in rat liver the expression of genes coding for the core proteins of fibromodulin, lumican and aggrecan. By means of Northern analysis and in situ hybridization we present evidence for their differential transcription during liver fibrogenesis. Whereas no fibromodulin expression could been detected, both lumican and aggrecan transcripts were found displaying different time‐courses of expression during the fibrogenic process. Based on studies performed in non‐hepatic tissues, these proteoglycans are considered to have keratan sulphate glycosaminoglycan side chains. The expression of the respective core protein genes in liver is unexpected since published data have shown neither keratan sulphate nor its synthesis de novo in this tissue. The results also point to a putative role of aggrecan in the modulation of the inflammatory process in the liver.