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Binding of HIV‐1 gp120 to the nicotinic receptor
Author(s) -
Bracci Luisa,
Lozzi Luisa,
Rustici Mauro,
Neri Paolo
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81380-5
Subject(s) - nicotinic agonist , acetylcholine receptor , curare , receptor , nicotinic acetylcholine receptor , sequence homology , acetylcholine , binding site , molecular mimicry , chemistry , alpha 4 beta 2 nicotinic receptor , biology , biochemistry , microbiology and biotechnology , peptide sequence , neuroscience , pharmacology , antibody , genetics , gene
We previously described a significant sequence homology between HIV‐1 gp120 and the functional sites responsible for the specific binding of snake curare‐mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable the binding of HIV‐1 gp120 to nicotinic acetylcholine receptors in muscle cells and neurons.