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Plasma membrane redox activity correlates with N‐ myc expression in neuroblastoma cells
Author(s) -
Medina Miguel Angel,
del Castillo-Olivares Antonio,
Schweigerer Lothar
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81376-w
Subject(s) - neuroblastoma , redox , chemistry , membrane , microbiology and biotechnology , biophysics , biochemistry , biology , cell culture , genetics , inorganic chemistry
In different neuroblastoma cell lines and transfected clones, an increasing plasma membrane redox activity correlates with amplification and enhanced expression of the N‐ myc oncogene. Furthermore, plasma membrane redox activity is partially inhibited by retinoic acid in neuroblastoma cells with multiple copies of the N‐ myc oncogene but not in neuroblastoma cells with only one copy of this gene.