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Intracellular signal transduction pathways that control pancreatic β‐cell proliferation
Author(s) -
Sjöholm Åke
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81373-t
Subject(s) - intracellular , signal transduction , protein kinase c , cell growth , microbiology and biotechnology , protein kinase a , second messenger system , inositol , biochemistry , gtp' , chemistry , kinase , biology , receptor , enzyme
This review focuses on the factors that regulate the proliferation of pancreatic islet β‐cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol esters and cyclic AMP analogs are all able to stimulate or inhibit β‐cell proliferation in a time‐ and concentration‐dependent manner. The evidence for involvement of cyclic AMP, cyclic GMP, protein kinase C, inositol polyphosphates, GTP‐binding proteins, polyamines and oncogenes is reviewed.