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Enhanced IgG‐ and complement‐independent phagocytosis of sulfatide‐enriched human erythrocytes by human monocytes
Author(s) -
Serra Maria Vittoria,
Mannu Franca,
Matera Aida,
Turrini Franco,
Arese Paolo
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)81369-w
Subject(s) - phagocytosis , opsonin , chemistry , immunoglobulin g , antibody opsonization , antibody , incubation , von willebrand factor , platelet , microbiology and biotechnology , immunology , biology , biochemistry
Phagocytosis by adherent human monocytes of human erythrocytes (RBC), sulfatide‐enriched by incubation with 10 −12 to 10 −9 M cerebroside sulfate, was enhanced approx. 6‐fold. Increased phagocytosis was observed only in RBC opsonized with fresh plasma, and not in non‐opsonized or serum‐opsonized RBC. Increased phagocytosis was immunoglobulin‐ and complement independent. Thrombospondin and von Willebrand factor, present in plasma but not in serum, and binding selectively to sulfatides, are likely mediators of the enhanced phagocytosis.